diff --git a/packages/react-dom/src/__tests__/ReactServerRendering-test.js b/packages/react-dom/src/__tests__/ReactServerRendering-test.js
index c071d3ff47b5..4a78a17117af 100644
--- a/packages/react-dom/src/__tests__/ReactServerRendering-test.js
+++ b/packages/react-dom/src/__tests__/ReactServerRendering-test.js
@@ -147,7 +147,7 @@ describe('ReactDOMServer', () => {
     it('should throw with silly args', () => {
       expect(
         ReactDOMServer.renderToString.bind(ReactDOMServer, {x: 123}),
-      ).toThrowError(
+      ).toThrow(
         'Objects are not valid as a React child (found: object with keys {x})',
       );
     });
@@ -155,7 +155,7 @@ describe('ReactDOMServer', () => {
     it('should throw prop mapping error for an <iframe /> with invalid props', () => {
       expect(() => {
         ReactDOMServer.renderToString(<iframe style="border:none;" />);
-      }).toThrowError(
+      }).toThrow(
         'The `style` prop expects a mapping from style properties to values, not ' +
           "a string. For example, style={{marginRight: spacing + 'em'}} when using JSX.",
       );
@@ -290,7 +290,7 @@ describe('ReactDOMServer', () => {
     it('should throw with silly args', () => {
       expect(
         ReactDOMServer.renderToStaticMarkup.bind(ReactDOMServer, {x: 123}),
-      ).toThrowError(
+      ).toThrow(
         'Objects are not valid as a React child (found: object with keys {x})',
       );
     });
@@ -715,7 +715,7 @@ describe('ReactDOMServer', () => {
             <span key={2} />
           </Wrapper>,
         );
-      }).toThrowError(/Cannot assign to read only property.*/);
+      }).toThrow(/Cannot assign to read only property.*/);
     } else {
       expect(
         ReactDOMServer.renderToStaticMarkup(
@@ -966,7 +966,7 @@ describe('ReactDOMServer', () => {
 
     expect(() => {
       ReactDOMServer.renderToString(<Foo />);
-    }).toThrow("Cannot read property 'world' of undefined");
+    }).toThrow("Cannot read properties of undefined (reading 'world')");
   });
 
   it('should warn when class contextType is undefined', () => {
@@ -981,7 +981,7 @@ describe('ReactDOMServer', () => {
 
     expect(() => {
       ReactDOMServer.renderToString(<Foo />);
-    }).toThrow("Cannot read property 'world' of undefined");
+    }).toThrow("Cannot read properties of undefined (reading 'world')");
     assertConsoleErrorDev([
       'Foo defines an invalid contextType. ' +
         'contextType should point to the Context object returned by React.createContext(). ' +
@@ -1007,7 +1007,7 @@ describe('ReactDOMServer', () => {
 
     expect(() => {
       ReactDOMServer.renderToString(<Foo />);
-    }).toThrow("Cannot read property 'hello' of undefined");
+    }).toThrow("Cannot read properties of undefined (reading 'hello')");
     assertConsoleErrorDev([
       'Foo defines an invalid contextType. ' +
         'contextType should point to the Context object returned by React.createContext(). ' +
@@ -1026,7 +1026,7 @@ describe('ReactDOMServer', () => {
 
     expect(() => {
       ReactDOMServer.renderToString(<Foo />);
-    }).toThrow("Cannot read property 'world' of undefined");
+    }).toThrow("Cannot read properties of undefined (reading 'world')");
     assertConsoleErrorDev([
       'Foo defines an invalid contextType. ' +
         'contextType should point to the Context object returned by React.createContext(). ' +
diff --git a/packages/react-reconciler/src/__tests__/ReactHooksWithNoopRenderer-test.js b/packages/react-reconciler/src/__tests__/ReactHooksWithNoopRenderer-test.js
index f48a78de4afb..425b3aade7e1 100644
--- a/packages/react-reconciler/src/__tests__/ReactHooksWithNoopRenderer-test.js
+++ b/packages/react-reconciler/src/__tests__/ReactHooksWithNoopRenderer-test.js
@@ -234,7 +234,7 @@ describe('ReactHooksWithNoopRenderer', () => {
 
   it('throws when called outside the render phase', async () => {
     expect(() => useState(0)).toThrow(
-      "Cannot read property 'useState' of null",
+      "Cannot read properties of null (reading 'useState')",
     );
     assertConsoleErrorDev([
       'Invalid hook call. Hooks can only be called inside of the body of a function component. This could happen for' +
diff --git a/scripts/jest/matchers/toThrow.js b/scripts/jest/matchers/toThrow.js
deleted file mode 100644
index 204a2fc713ca..000000000000
--- a/scripts/jest/matchers/toThrow.js
+++ /dev/null
@@ -1,50 +0,0 @@
-'use strict';
-
-// V8 uses a different message format when reading properties of null or undefined.
-// Older versions use e.g. "Cannot read property 'world' of undefined"
-// Newer versions use e.g. "Cannot read properties of undefined (reading 'world')"
-// This file overrides the built-in toThrow() matches to handle both cases,
-// enabling the React project to support Node 12-16 without forking tests.
-
-const toThrowMatchers = require('expect/build/toThrowMatchers').default;
-const builtInToThrow = toThrowMatchers.toThrow;
-
-// Detect the newer stack format:
-let newErrorFormat = false;
-try {
-  null.test();
-} catch (error) {
-  if (error.message.includes('Cannot read properties of null')) {
-    newErrorFormat = true;
-  }
-}
-
-// Detect the message pattern we need to rename:
-const regex = /Cannot read property '([^']+)' of (.+)/;
-
-// Massage strings (written in the older format) to match the newer format
-// if tests are currently running on Node 16+
-function normalizeErrorMessage(message) {
-  if (newErrorFormat) {
-    const match = message.match(regex);
-    if (match) {
-      return `Cannot read properties of ${match[2]} (reading '${match[1]}')`;
-    }
-  }
-
-  return message;
-}
-
-function toThrow(value, expectedValue) {
-  if (typeof expectedValue === 'string') {
-    expectedValue = normalizeErrorMessage(expectedValue);
-  } else if (expectedValue instanceof Error) {
-    expectedValue.message = normalizeErrorMessage(expectedValue.message);
-  }
-
-  return builtInToThrow.call(this, value, expectedValue);
-}
-
-module.exports = {
-  toThrow,
-};
diff --git a/scripts/jest/setupTests.js b/scripts/jest/setupTests.js
index 28586d94b593..48e1a51f9436 100644
--- a/scripts/jest/setupTests.js
+++ b/scripts/jest/setupTests.js
@@ -47,7 +47,6 @@ if (process.env.REACT_CLASS_EQUIVALENCE_TEST) {
 
   expect.extend({
     ...require('./matchers/reactTestMatchers'),
-    ...require('./matchers/toThrow'),
   });
 
   // We have a Babel transform that inserts guards against infinite loops.
diff --git a/scripts/jest/spec-equivalence-reporter/setupTests.js b/scripts/jest/spec-equivalence-reporter/setupTests.js
index a561fb4b4d1d..e02839788325 100644
--- a/scripts/jest/spec-equivalence-reporter/setupTests.js
+++ b/scripts/jest/spec-equivalence-reporter/setupTests.js
@@ -60,5 +60,4 @@ afterEach(assertConsoleLogsCleared);
 
 expect.extend({
   ...require('../matchers/reactTestMatchers'),
-  ...require('../matchers/toThrow'),
 });