diff --git a/src/libraries/System.IO.IsolatedStorage/src/Resources/Strings.resx b/src/libraries/System.IO.IsolatedStorage/src/Resources/Strings.resx
index 8220d576e086a0..7575c8e979de03 100644
--- a/src/libraries/System.IO.IsolatedStorage/src/Resources/Strings.resx
+++ b/src/libraries/System.IO.IsolatedStorage/src/Resources/Strings.resx
@@ -140,5 +140,8 @@
   </data>
   <data name="PlatformNotSupported_CAS" xml:space="preserve">
     <value>Code Access Security is not supported on this platform.</value>
-  </data>  
+  </data>
+  <data name="IsolatedStorage_PlatformNotSupported" xml:space="preserve">
+    <value>System.IO.IsolatedStorage is not supported on this platform.</value>
+  </data>
 </root>
diff --git a/src/libraries/System.IO.IsolatedStorage/src/System.IO.IsolatedStorage.csproj b/src/libraries/System.IO.IsolatedStorage/src/System.IO.IsolatedStorage.csproj
index 4771f9f572c729..75bb5e2176c738 100644
--- a/src/libraries/System.IO.IsolatedStorage/src/System.IO.IsolatedStorage.csproj
+++ b/src/libraries/System.IO.IsolatedStorage/src/System.IO.IsolatedStorage.csproj
@@ -1,9 +1,12 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
-    <TargetFrameworks>$(NetCoreAppCurrent)-Windows_NT;$(NetCoreAppCurrent)-Unix;$(NetCoreAppCurrent)-Browser</TargetFrameworks>
+    <TargetFrameworks>$(NetCoreAppCurrent)-Windows_NT;$(NetCoreAppCurrent)-Unix;$(NetCoreAppCurrent)</TargetFrameworks>
 	<Nullable>enable</Nullable>
   </PropertyGroup>
-  <ItemGroup>
+  <PropertyGroup>
+    <GeneratePlatformNotSupportedAssemblyMessage Condition="'$(TargetsAnyOS)' == 'true'">SR.IsolatedStorage_PlatformNotSupported</GeneratePlatformNotSupportedAssemblyMessage>
+  </PropertyGroup>
+  <ItemGroup Condition="'$(TargetsAnyOS)' != 'true'">
     <Compile Include="System\IO\IsolatedStorage\IsolatedStorageException.cs" />
     <Compile Include="System\IO\IsolatedStorage\IsolatedStorageFile.cs" />
     <Compile Include="System\IO\IsolatedStorage\IsolatedStorageFileStream.cs" />
@@ -18,18 +21,20 @@
   <ItemGroup Condition="'$(TargetsWindows)' == 'true'">
     <Compile Include="System\IO\IsolatedStorage\Helper.Win32.cs" />
   </ItemGroup>
-  <ItemGroup Condition="'$(TargetsUnix)' == 'true' or '$(TargetsBrowser)' == 'true'">
+  <ItemGroup Condition="'$(TargetsUnix)' == 'true'">
     <Compile Include="System\IO\IsolatedStorage\Helper.Unix.cs" />
   </ItemGroup>
-  <ItemGroup>
+  <ItemGroup Condition="'$(TargetsAnyOS)' != 'true'">
     <Reference Include="System.IO.FileSystem" />
     <Reference Include="System.Linq" />
-    <Reference Include="System.Runtime" />
     <Reference Include="System.Runtime.Extensions" />
     <Reference Include="System.Security.Cryptography.Algorithms" />
     <Reference Include="System.Security.Cryptography.Primitives" />
     <Reference Include="System.Threading" />
   </ItemGroup>
+  <ItemGroup>
+    <Reference Include="System.Runtime" />
+  </ItemGroup>
   <ItemGroup Condition="'$(TargetsWindows)' == 'true'">
     <Reference Include="System.IO.FileSystem.AccessControl" />
     <Reference Include="System.Security.AccessControl" />
diff --git a/src/libraries/System.IO.IsolatedStorage/tests/AssemblyInfo.cs b/src/libraries/System.IO.IsolatedStorage/tests/AssemblyInfo.cs
index 9f1f18cb9e6d62..9a2e6238fb54a4 100644
--- a/src/libraries/System.IO.IsolatedStorage/tests/AssemblyInfo.cs
+++ b/src/libraries/System.IO.IsolatedStorage/tests/AssemblyInfo.cs
@@ -9,3 +9,4 @@
 // create unique identities for every test to allow every test to have
 // it's own store.
 [assembly: CollectionBehavior(CollectionBehavior.CollectionPerAssembly, DisableTestParallelization = true)]
+[assembly: SkipOnMono("System.IO.IsolatedStorage is not supported on Browser", TestPlatforms.Browser)]