diff --git a/.changeset/chilly-jars-jog.md b/.changeset/chilly-jars-jog.md
new file mode 100644
index 00000000000..cb414e294b4
--- /dev/null
+++ b/.changeset/chilly-jars-jog.md
@@ -0,0 +1,5 @@
+---
+"@primer/react": minor
+---
+
+Hide `TooltipV2` tooltips on `touchend` event
diff --git a/packages/react/src/TooltipV2/Tooltip.tsx b/packages/react/src/TooltipV2/Tooltip.tsx
index 9fe332b5dc8..1c50c8f10bc 100644
--- a/packages/react/src/TooltipV2/Tooltip.tsx
+++ b/packages/react/src/TooltipV2/Tooltip.tsx
@@ -146,14 +146,18 @@ export type TooltipProps = React.PropsWithChildren<
 > &
   React.HTMLAttributes<HTMLElement>
 
-type TriggerPropsType = {
-  'aria-describedby'?: string
-  'aria-labelledby'?: string
-  'aria-label'?: string
-  onBlur?: React.FocusEventHandler
-  onFocus?: React.FocusEventHandler
-  onMouseEnter?: React.MouseEventHandler
-  onMouseLeave?: React.MouseEventHandler
+type TriggerPropsType = Pick<
+  React.HTMLAttributes<HTMLElement>,
+  | 'aria-describedby'
+  | 'aria-labelledby'
+  | 'onBlur'
+  | 'onTouchEnd'
+  | 'onFocus'
+  | 'onMouseOverCapture'
+  | 'onMouseLeave'
+  | 'onTouchCancel'
+  | 'onTouchEnd'
+> & {
   ref?: React.RefObject<HTMLElement>
 }
 
@@ -214,7 +218,7 @@ export const Tooltip = React.forwardRef(
 
     const [isPopoverOpen, setIsPopoverOpen] = useState(false)
 
-    const timeoutRef = React.useRef<number | null>(null)
+    const openTimeoutRef = React.useRef<number | null>(null)
 
     const {safeSetTimeout, safeClearTimeout} = useSafeTimeout()
 
@@ -261,6 +265,10 @@ export const Tooltip = React.forwardRef(
       }
     }
     const closeTooltip = () => {
+      if (openTimeoutRef.current) {
+        safeClearTimeout(openTimeoutRef.current)
+        openTimeoutRef.current = null
+      }
       try {
         if (
           tooltipElRef.current &&
@@ -362,6 +370,13 @@ export const Tooltip = React.forwardRef(
                 closeTooltip()
                 child.props.onBlur?.(event)
               },
+              onTouchEnd: (event: React.TouchEvent) => {
+                child.props.onTouchEnd?.(event)
+
+                // Hide tooltips on tap to essentially disable them on touch devices;
+                // this still allows viewing the tooltip on tap-and-hold
+                safeSetTimeout(() => closeTooltip(), 10)
+              },
               onFocus: (event: React.FocusEvent) => {
                 // only show tooltip on :focus-visible, not on :focus
                 try {
@@ -374,19 +389,17 @@ export const Tooltip = React.forwardRef(
                 openTooltip()
                 child.props.onFocus?.(event)
               },
-              onMouseEnter: (event: React.MouseEvent) => {
-                // show tooltip after mosue has been hovering for at least 50ms
+              onMouseOverCapture: (event: React.MouseEvent) => {
+                // We use a `capture` event to ensure this is called first before
+                // events that might cancel the opening timeout (like `onTouchEnd`)
+                // show tooltip after mouse has been hovering for at least 50ms
                 // (prevent showing tooltip when mouse is just passing through)
-                timeoutRef.current = safeSetTimeout(() => {
+                openTimeoutRef.current = safeSetTimeout(() => {
                   openTooltip()
                   child.props.onMouseEnter?.(event)
                 }, 50)
               },
               onMouseLeave: (event: React.MouseEvent) => {
-                if (timeoutRef.current) {
-                  safeClearTimeout(timeoutRef.current)
-                  timeoutRef.current = null
-                }
                 closeTooltip()
                 child.props.onMouseLeave?.(event)
               },
diff --git a/packages/react/src/__tests__/__snapshots__/TextInput.test.tsx.snap b/packages/react/src/__tests__/__snapshots__/TextInput.test.tsx.snap
index 3d19d97cca1..818ffd62114 100644
--- a/packages/react/src/__tests__/__snapshots__/TextInput.test.tsx.snap
+++ b/packages/react/src/__tests__/__snapshots__/TextInput.test.tsx.snap
@@ -3325,8 +3325,9 @@ exports[`TextInput renders trailingAction icon button 1`] = `
       onBlur={[Function]}
       onClick={[MockFunction]}
       onFocus={[Function]}
-      onMouseEnter={[Function]}
       onMouseLeave={[Function]}
+      onMouseOverCapture={[Function]}
+      onTouchEnd={[Function]}
       type="button"
     >
       <svg
@@ -4090,8 +4091,9 @@ exports[`TextInput renders trailingAction text button with a tooltip 1`] = `
       onBlur={[Function]}
       onClick={[MockFunction]}
       onFocus={[Function]}
-      onMouseEnter={[Function]}
       onMouseLeave={[Function]}
+      onMouseOverCapture={[Function]}
+      onTouchEnd={[Function]}
       style={
         {
           "--button-color": "fg.subtle",