Before freelancing, I spent a decade at Genentech as a Senior Principal Scientist and Group Leader in the gRED Computational Sciences Hub, working across biostatistics, scientific software engineering, and team leadership to build scalable, modular tools for functional genomics. Check out our crisprVerse. Selected CRISPR-related publications:

• crisprVerse: design of CRISPR guide RNAs across nucleases and technologies, Nature Communications
• enAsCas12a ultra-compact CRISPR screening libraries, Nature Communications
• Biases in genome-wide pooled CRISPR screening, Genome Biology
• Enhanced scalable mutagenic base editor platform, Cell Reports
• Genome-wide murine CRISPR activation (CRISPRa) libraries, bioRxiv

And before Genentech, I got my PhD degree in Biostatistics at Johns Hopkins University under the supervision of Dr. Kasper Hansen, during which I focused on developing statistical methodology for the analysis of methylation array. I then pursued a postdoctoral degree in Neuroinformatics at the University of Pennsylvania with Dr. Taki Shinohara. My work focused on the multi-scanner harmonization and normalization of different neuroimaging modalities (MRI, DTI, etc). Selected works from my academic life:

• Functional normalization for methylation arrays (minfi), Genome Biology
• Hi-C reconstruction from methylation data, Genome Biology
• Processing of Illumina EPIC arrays, Bioinformatics
• shinyMethy: interactive visualization of methylation arrays, F1000Research
• Harmonization of structural MRI, Neuroimage
• Harmonization of DTI, Neuroimage
• Harmonization of cortical thickness measurements, Neuroimage

Package	BioC-release	BioC-devel	Description
crisprVerse			Easily install of the crisprVerse ecosystem
crisprDesign			Core gRNA design package across nucleases and applications
crisprBase			Base functions and classes for CRISPR gRNA design
crisprBowtie			Alignment of gRNA spacer sequences using bowtie
crisprBwa			Alignment of gRNA spacer sequences using BWA
crisprScore			On-target and off-target scoring for CRISPR gRNAs
crisprScoreData			Pre-trained models for the crisprScore package
crisprViz			Visualization of CRISPR gRNAs using genomic tracks
crisprShiny			Shiny interface for CRISPR gRNAs
Rbwa			R wrapper for BWA-backtrack and BWA-MEM aligners
ARRmNormalization			Normalization for methylation arrays
shinyMethyl			Interactive visualization for Illumina methylation arrays

Package	BioC-release	BioC-devel	Description
minfi			Analyze Illumina Infinium DNA methylation arrays
screenCounter			Counting Reads in High-Throughput Sequencing Screens