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@OmniBioAI

OmniBioAI

AI-native bioinformatics platform for multi-omics analysis, workflow orchestration, reproducible science, and computational biology.

🧬 OmniBioAI Studio

AI-Native Bioinformatics Platform for the Future of Computational Biology

OmniBioAI Studio is an AI-native bioinformatics platform designed to accelerate scientific discovery through intelligent automation, reproducible workflows, and scalable computational infrastructure.

It provides a unified environment for genomics, multi-omics, AI-driven biological reasoning, workflow orchestration, and reproducible computational research across local machines, HPC clusters, and cloud environments.

🚀 Built for researchers, computational scientists, and developers building the next generation of biomedical AI systems.


📊 By the Numbers

3M+ lines of code30,000+ tests across 1,300+ test files
33 repositories231 bioinformatics/ML plugins
1,233 container images on GHCR (1,000 ARM64 SIF + Docker)616 workflow bundles (Nextflow, WDL, CWL, Snakemake)
36M PubMed abstracts indexed12,110 execution, cloud, HPC, and orchestration tools

📊 Live platform metrics & health → — real-time architecture, codebase stats, and service status, not just claims.


🌐 Platform Overview

OmniBioAI connects biological data, computational workflows, AI models, and scientific knowledge into a unified ecosystem.

Biological Data
│
▼
┌──────────────────────┐
│ OmniBioAI Platform │
└──────────────────────┘
│
├── 🧬 Multi-Omics Analysis
├── 🤖 AI Agents & Scientific Reasoning
├── ⚙️ Workflow Orchestration
├── 🐳 Containerized Execution
├── 🖥 HPC & Cloud Compute
├── 📚 Knowledge Retrieval & RAG
├── 🔐 Security & Governance
└── 🔬 Reproducible Research

✨ Core Capabilities

🧬 Multi-Omics Computing

Support for modern computational biology workflows:

  • Genomics
  • Transcriptomics
  • Single-cell RNA sequencing
  • Proteomics
  • Variant analysis
  • Functional annotation
  • Biological pathway analysis
  • Knowledge-driven discovery

🤖 AI-Powered Scientific Intelligence

OmniBioAI integrates AI systems designed for biological reasoning:

  • AI-assisted workflow generation
  • Biomedical knowledge retrieval
  • Literature-aware analysis
  • Scientific hypothesis generation
  • Agent-driven computational workflows
  • Model-assisted interpretation

⚙️ Unified Workflow Execution

Execute bioinformatics pipelines across multiple environments:

  • Local workstation
  • HPC clusters
  • Slurm environments
  • Cloud batch systems
  • Containerized compute environments

616 versioned workflow bundles across:

  • Nextflow
  • WDL
  • Snakemake
  • CWL

🏗️ Platform Architecture

OmniBioAI Architecture

Unified AI-Native Bioinformatics Platform — 9-layer architecture from client access through security, observability, and development environments.


🧩 Ecosystem Repositories

🚀 Core Platform

RepositoryDescription
omnibioaiMain Django workbench + 231 plugins
omnibioai-studioElectron desktop app — orchestrates the full stack
omnibioai-control-centerPlatform monitoring and operational dashboard
omnibioai-workbenchPlugin execution environment
omnibioai-launcherOpens registry objects in Jupyter, VS Code, and RStudio
omnibioai-sdkPython SDK client
omnibioai-utilsEcosystem automation — stack lifecycle, CI/CD, coverage reporting

⚙️ Workflow & Execution

RepositoryDescription
omnibioai-tesTool Execution Service for local, HPC, and cloud execution
omnibioai-toolserverFastAPI tool API
omnibioai-tool-runtimeCloud-agnostic container execution runtime
omnibioai-tool-imagesBioinformatics and ML container images
omnibioai-workflow-bundlesVersioned reproducible workflow packages

🤖 AI & Knowledge Systems

RepositoryDescription
omnibioai-ragBiomedical retrieval augmented generation system
omnibioai-dev-hubAI intelligence hub with semantic retrieval
omnibioai-model-registryML model lifecycle and provenance management

🔐 Security & Governance

RepositoryDescription
omnibioai-authAuthentication and identity services
omnibioai-api-gatewayZero-trust API gateway
omnibioai-policy-engineRBAC/ABAC policy enforcement
omnibioai-hpc-policy-engineGPU/CPU quota governance
omnibioai-security-auditSecurity events and observability
omnibioai-security-sdkShared security framework
omnibioai-iam-clientIdentity and access management client
omnibioai-usage-clientUsage-metering event-emission SDK

💰 Billing & Operations

RepositoryDescription
omnibioai-billingSubscription billing, invoicing, and entitlement catalog
omnibioai-db-initMySQL database initialization scripts
omnibioai-dev-dockerGPU/DGX development environment image (CUDA, PyTorch)

🧪 Research Infrastructure

RepositoryDescription
omnibioai-limsBiological sample and metadata management
omnibioai-dataReference and example datasets
omnibioai-docsTechnical documentation
omnibioai-videosTutorials and onboarding resources

🎨 Design & Frontend

RepositoryDescription
omnibioai-design-tokensShared design tokens and theme
omnibioai-uiShared UI component library
omnibioai-landingPublic-facing landing page

🔬 Design Principles

Reproducibility First

Every analysis should be traceable:

  • Input provenance
  • Reference versions
  • Tool versions
  • Execution environment
  • Workflow history
  • Output artifacts

AI With Scientific Guardrails

OmniBioAI follows:

✅ Deterministic execution before AI reasoning ✅ Evidence-based biological interpretation ✅ Human review for critical decisions ✅ Complete computational provenance


🛠️ Technology Stack

Backend

  • Python
  • FastAPI
  • Django
  • MySQL
  • Redis Streams

Frontend

  • React
  • TypeScript
  • Vite
  • Design systems

AI

  • Large Language Models
  • Retrieval Augmented Generation
  • Vector search
  • Knowledge graphs
  • Scientific agents

Infrastructure

  • Docker
  • Kubernetes
  • Slurm
  • Cloud batch computing

🚀 Getting Started

🌐 Websitehttps://omnibioai.org

📊 Live Platform Statshttps://control.omnibioai.org

🐙 GitHub Organizationhttps://github.com/OmniBioAI

📦 Container Registry (1,233 images)https://github.com/orgs/OmniBioAI/packages

🤗 Hugging Facehttps://huggingface.co/omnibioai

📚 Documentation See the omnibioai-docs repository

🎥 Tutorials See the omnibioai-videos repository

💬 Discordhttps://discord.gg/Hu6vgfAFn

🐦 Twitterhttps://twitter.com/OmniBioAI


👨‍💻 Creator

Created by Manish Kumar

🧬 Senior Computational Scientist | 🤖 AI-Native Bioinformatics Engineer

18 years across 🇺🇸 USA, 🇶🇦 Qatar, 🇲🇾 Malaysia, 🇸🇦 Saudi Arabia, and 🇮🇳 India, building genomics and precision medicine infrastructure for research and clinical environments.

🏥 Currently at the University of Kansas Medical Center — genomics, single-cell, exome & proteomics pipelines for rare disease and translational research.

Building intelligent computational systems at the intersection of:

Biology × AI × Software Engineering × HPC


🌟 Vision

Build the operating layer where biological data, computational workflows, and artificial intelligence converge to accelerate discovery.


⭐ Star the repositories, explore the architecture, and join the future of AI-powered computational biology.

Popular repositories Loading

  1. omnibioai-studio omnibioai-studioPublic

    Electron + React + Vite desktop app for OmniBioAI — provides a visual workflow builder, plugin launcher, and unified control plane for local, HPC, and cloud bioinformatics execution. Connects to th…

    JavaScript 2

  2. omnibioai-hpc-policy-engine omnibioai-hpc-policy-enginePublic

    Compute-aware HPC policy and resource governance engine for OmniBioAI — enforces GPU/CPU quota limits, Slurm-aware scheduling policies, cluster access control, and zero-trust execution decisions. P…

    Python 2

  3. omnibioai-dev-docker omnibioai-dev-dockerPublic

    Full GPU-accelerated AI development environment for OmniBioAI — built on NVIDIA PyTorch 25.10 with CUDA, includes R, MySQL, JupyterLab, Hugging Face Transformers, and Ollama. Designed for bioinform…

    Python 1

  4. omnibioai-toolserver omnibioai-toolserverPublic

    FastAPI-based ToolServer for OmniBioAI — provides validated, asynchronous execution APIs for bioinformatics tools. Accepts tool invocation requests, validates inputs against declared schemas, execu…

    Python 1

  5. omnibioai-sdk omnibioai-sdkPublic

    Official Python SDK for OmniBioAI — typed client for the object registry API (list, filter, paginate, fetch by ID), notebook launch integration for JupyterLab and RStudio, and authentication helper…

    Python 1

  6. omnibioai-tool-runtime omnibioai-tool-runtimePublic

    Minimal cloud-agnostic container execution runtime for the OmniBioAI Tool Execution Service — enforces a strict input/output contract for tools running on AWS Batch, Azure Batch, and Kubernetes. Ha…

    Python 1

Repositories

Showing 10 of 25 repositories
  • omnibioai-control-center Public

    FastAPI-based control plane for OmniBioAI — provides HTTP/TCP/disk health monitoring across all platform services, live operational dashboards, and ecosystem-wide report generation (architecture diagrams, codebase stats, test coverage, system health summaries). Single pane of glass for platform operators.

    OmniBioAI/omnibioai-control-center's past year of commit activity
    Python 1 0 0 0 Updated Aug 22, 2026
  • omnibioai-model-registry Public

    Production-grade ML model registry for OmniBioAI — versioned storage, SHA-256 integrity verification, provenance tracking, and full lifecycle management (register, promote, deprecate, retire) for AI/ML models across local disk, cloud object storage, and HPC filesystems. Supports audit trails and model lineage queries.

    OmniBioAI/omnibioai-model-registry's past year of commit activity
    Python 1 0 0 0 Updated Aug 22, 2026
  • omnibioai-landing Public

    Official public landing page for OmniBioAI Studio — static HTML/CSS/JS site covering platform features, multi-omics pipeline coverage, system requirements, download links for all platforms (macOS DMG, Linux AppImage, Windows EXE), and a beta access request form. No build step required.

    OmniBioAI/omnibioai-landing's past year of commit activity
    HTML 1 0 0 0 Updated Aug 22, 2026
  • omnibioai-studio Public

    Electron + React + Vite desktop app for OmniBioAI — provides a visual workflow builder, plugin launcher, and unified control plane for local, HPC, and cloud bioinformatics execution. Connects to the Django backend via IPC and REST, integrates Docker runtime and local LLM inference via Ollama.

    OmniBioAI/omnibioai-studio's past year of commit activity
    JavaScript 2MIT 0 6 0 Updated Aug 19, 2026
  • omnibioai-api-gateway Public

    Zero-trust API gateway for OmniBioAI — handles authentication (JWT verification), policy enforcement (RBAC/ABAC), request routing to downstream services, rate limiting, and secure service-to-service communication. All inbound traffic to the platform passes through this gateway; no service is directly addressable without authorization.

    OmniBioAI/omnibioai-api-gateway's past year of commit activity
    Python 1 0 2 0 Updated Aug 19, 2026
  • omnibioai-auth Public

    Production-grade FastAPI authentication service for OmniBioAI — JWT-based login with access and refresh tokens, role-based access control (RBAC), MySQL-backed user and role management, OAuth2 password flow, and token revocation. Central identity provider for all platform services.

    OmniBioAI/omnibioai-auth's past year of commit activity
    Python 1 0 2 0 Updated Aug 18, 2026
  • omnibioai-security-audit Public

    Distributed security audit and observability system for OmniBioAI — Redis Streams-based real-time event pipeline capturing authentication events, policy decisions, data access, and system actions across all platform services. Provides zero-trust traceability, tamper-evident audit logs, and scalable event replay for compliance and forensics.

    OmniBioAI/omnibioai-security-audit's past year of commit activity
    Python 1 0 0 0 Updated Aug 17, 2026
  • omnibioai-toolserver Public

    FastAPI-based ToolServer for OmniBioAI — provides validated, asynchronous execution APIs for bioinformatics tools. Accepts tool invocation requests, validates inputs against declared schemas, executes tools in isolation, and returns structured results. Acts as the execution boundary between the platform and individual tools.

    OmniBioAI/omnibioai-toolserver's past year of commit activity
    Python 1 0 2 0 Updated Aug 17, 2026
  • omnibioai-work Public

    Runtime working directory for the OmniBioAI platform — stores workflow outputs, tool run artifacts, and pipeline results.

    OmniBioAI/omnibioai-work's past year of commit activity
    Shell 1 0 0 0 Updated Aug 14, 2026
  • omnibioai-tool-images Public

    ARM64-compatible Docker and Singularity images for bioinformatics and ML tools — FastQC, STAR, BWA, GATK, DESeq2, PyTorch, and more. Built for NVIDIA DGX Spark (aarch64) and deployable via Slurm. Declarative YAML-driven image definitions; part of the OmniBioAI reproducible tool execution stack.

    OmniBioAI/omnibioai-tool-images's past year of commit activity
    Shell 1 0 1 0 Updated Aug 8, 2026

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