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DestinyNet

Description

This repository contains the code for the paper "DestinyNet: A Deep Learning-Based Single-Cell Lineage Tracing Framework for Fate Clustering, Flow, and Prediction". The website is available in https://destinynet.readthedocs.io/en/latest/index.html

Introduction

We have developed a simple deep learning framework yet is able to encode single-cell RNA sequencing data, clonal information and descendant cell types of clones to decode the fate of any undetermined cell in three ways.

image

Model Architecture

image

How to Use?

  1. Install the required environment

    pip install -r requirements.txt
  2. Install the latest version of DestinyNet

    pip install DestinyNet
  3. Modify the parameters in util.py, or use the default parameters

  4. Example usage

    importDestinyNetargs=DestinyNet.get_args()
    DestinyNet.train(args)

Data Access

The hematopoiesis dataset (Weinreb) can be accessed at the Gene Expression Omnibus database with accession number GSE140802, the reprogramming dataset with accession number GSE99915 and the hematopoiesis (Pei) dataset with accession number GSE144273, the hematopoiesis dataset (Bowling) with accession number GSE146972, the hematopoiesis dataset (Li) with accession number GSE222486, the lung dataset with accession numbers GSE137805 and GSE137811.

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GitHub - WanluLiuLab/DestinyNet · GitHub
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DestinyNet

Description

This repository contains the code for the paper "DestinyNet: A Deep Learning-Based Single-Cell Lineage Tracing Framework for Fate Clustering, Flow, and Prediction". The website is available in https://destinynet.readthedocs.io/en/latest/index.html

Introduction

We have developed a simple deep learning framework yet is able to encode single-cell RNA sequencing data, clonal information and descendant cell types of clones to decode the fate of any undetermined cell in three ways.

image

Model Architecture

image

How to Use?

  1. Install the required environment

    pip install -r requirements.txt
  2. Install the latest version of DestinyNet

    pip install DestinyNet
  3. Modify the parameters in util.py, or use the default parameters

  4. Example usage

    importDestinyNetargs=DestinyNet.get_args()
    DestinyNet.train(args)

Data Access

The hematopoiesis dataset (Weinreb) can be accessed at the Gene Expression Omnibus database with accession number GSE140802, the reprogramming dataset with accession number GSE99915 and the hematopoiesis (Pei) dataset with accession number GSE144273, the hematopoiesis dataset (Bowling) with accession number GSE146972, the hematopoiesis dataset (Li) with accession number GSE222486, the lung dataset with accession numbers GSE137805 and GSE137811.

About

No description, website, or topics provided.

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1 watching

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, 'i'); if (__m === '*' || __re.test(location.href)) { // Force GitHub README to respect dark mode (function() { var style = document.createElement('style'); style.textContent = ' .markdown-body { color-scheme: dark light; } .markdown-body pre { background: #161b22 !important; } .markdown-body code { background: rgba(110, 118, 129, 0.4) !important; } .markdown-body table th, .markdown-body table td { border-color: #30363d !important; } .markdown-body img { background: #0d1117; } .markdown-body blockquote { border-left-color: #8b949e; } .markdown-body hr { border-color: #30363d; } '; document.head.appendChild(style); })(); } } catch(__e) { console.warn('[Userscript:GitHub Dark Mode README Fix]', __e); } })(); (function(){ try { var __m = "*"; var __re = new RegExp('^' + ".*" + ' GitHub - WanluLiuLab/DestinyNet · GitHub
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DestinyNet

Description

This repository contains the code for the paper "DestinyNet: A Deep Learning-Based Single-Cell Lineage Tracing Framework for Fate Clustering, Flow, and Prediction". The website is available in https://destinynet.readthedocs.io/en/latest/index.html

Introduction

We have developed a simple deep learning framework yet is able to encode single-cell RNA sequencing data, clonal information and descendant cell types of clones to decode the fate of any undetermined cell in three ways.

image

Model Architecture

image

How to Use?

  1. Install the required environment

    pip install -r requirements.txt
  2. Install the latest version of DestinyNet

    pip install DestinyNet
  3. Modify the parameters in util.py, or use the default parameters

  4. Example usage

    importDestinyNetargs=DestinyNet.get_args()
    DestinyNet.train(args)

Data Access

The hematopoiesis dataset (Weinreb) can be accessed at the Gene Expression Omnibus database with accession number GSE140802, the reprogramming dataset with accession number GSE99915 and the hematopoiesis (Pei) dataset with accession number GSE144273, the hematopoiesis dataset (Bowling) with accession number GSE146972, the hematopoiesis dataset (Li) with accession number GSE222486, the lung dataset with accession numbers GSE137805 and GSE137811.

About

No description, website, or topics provided.

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1 watching

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Languages

, 'i'); if (__m === '*' || __re.test(location.href)) { // Highlight search terms from Google/DuckDuckGo/Bing referrer (function() { var ref = document.referrer; var terms = []; if (ref.includes('google.com') || ref.includes('duckduckgo.com') || ref.includes('bing.com')) { var url = new URL(ref); var q = url.searchParams.get('q') || url.searchParams.get('p'); if (q) { terms = q.split(/\s+/).filter(function(t) { return t.length > 2; }); } } if (terms.length === 0) return; var style = document.createElement('style'); style.textContent = '.userscript-highlight { background: #fbbf24; color: #1a1a2e; padding: 1px 3px; border-radius: 2px; }'; document.head.appendChild(style); function highlight(node) { if (node.nodeType === 3) { // text node var text = node.textContent; var found = false; terms.forEach(function(term) { var regex = new RegExp('(' + term.replace(/[.*+?^${}()|[\]\\]/g, '\\') + ')', 'gi'); if (regex.test(text)) { found = true; var frag = document.createDocumentFragment(); var parts = text.split(regex); parts.forEach(function(part, i) { if (i % 2 === 0) { frag.appendChild(document.createTextNode(part)); } else { var span = document.createElement('span'); span.className = 'userscript-highlight'; span.textContent = part; frag.appendChild(span); } }); node.parentNode.replaceChild(frag, node); } }); } else if (node.nodeType === 1 && node.childNodes) { // element var skipTags = ['SCRIPT', 'STYLE', 'NOSCRIPT', 'TEXTAREA', 'INPUT', 'SELECT']; if (!skipTags.includes(node.tagName)) { Array.from(node.childNodes).forEach(highlight); } } } highlight(document.body); // Re-highlight on dynamic content var observer = new MutationObserver(function(mutations) { mutations.forEach(function(m) { m.addedNodes.forEach(function(node) { if (node.nodeType === 1 || node.nodeType === 3) highlight(node); }); }); }); observer.observe(document.body, { childList: true, subtree: true }); })(); } } catch(__e) { console.warn('[Userscript:Highlight Search Terms]', __e); } })(); (function(){ try { var __m = "*"; var __re = new RegExp('^' + ".*" + ' GitHub - WanluLiuLab/DestinyNet · GitHub
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DestinyNet

Description

This repository contains the code for the paper "DestinyNet: A Deep Learning-Based Single-Cell Lineage Tracing Framework for Fate Clustering, Flow, and Prediction". The website is available in https://destinynet.readthedocs.io/en/latest/index.html

Introduction

We have developed a simple deep learning framework yet is able to encode single-cell RNA sequencing data, clonal information and descendant cell types of clones to decode the fate of any undetermined cell in three ways.

image

Model Architecture

image

How to Use?

  1. Install the required environment

    pip install -r requirements.txt
  2. Install the latest version of DestinyNet

    pip install DestinyNet
  3. Modify the parameters in util.py, or use the default parameters

  4. Example usage

    importDestinyNetargs=DestinyNet.get_args()
    DestinyNet.train(args)

Data Access

The hematopoiesis dataset (Weinreb) can be accessed at the Gene Expression Omnibus database with accession number GSE140802, the reprogramming dataset with accession number GSE99915 and the hematopoiesis (Pei) dataset with accession number GSE144273, the hematopoiesis dataset (Bowling) with accession number GSE146972, the hematopoiesis dataset (Li) with accession number GSE222486, the lung dataset with accession numbers GSE137805 and GSE137811.

About

No description, website, or topics provided.

Resources

Stars

1 star

Watchers

1 watching

Forks

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Used by

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Languages

, 'i'); if (__m === '*' || __re.test(location.href)) { // Strip utm_, fbclid, gclid, etc. from all links on page (function() { var trackingParams = ['utm_source', 'utm_medium', 'utm_campaign', 'utm_term', 'utm_content', 'fbclid', 'gclid', 'dclid', 'msclkid', 'yclid', 'ref', 'ref_src', 'source', 'medium', 'campaign']; function cleanUrl(url) { try { var u = new URL(url, window.location.origin); var changed = false; trackingParams.forEach(function(p) { if (u.searchParams.has(p)) { u.searchParams.delete(p); changed = true; } }); return changed ? u.toString() : url; } catch (e) { return url; } } function cleanLinks() { document.querySelectorAll('a[href]').forEach(function(a) { var clean = cleanUrl(a.href); if (clean !== a.href) a.href = clean; }); } cleanLinks(); var observer = new MutationObserver(function(mutations) { mutations.forEach(function(m) { m.addedNodes.forEach(function(node) { if (node.nodeType === 1) { if (node.tagName === 'A') cleanLinks(); node.querySelectorAll('a[href]').forEach(function(a) { var clean = cleanUrl(a.href); if (clean !== a.href) a.href = clean; }); } }); }); }); observer.observe(document.body, { childList: true, subtree: true }); })(); } } catch(__e) { console.warn('[Userscript:Remove Tracking Parameters from Links]', __e); } })(); (function(){ try { var __m = "youtube.com"; var __re = new RegExp('^' + "youtube\\.com" + ' GitHub - WanluLiuLab/DestinyNet · GitHub
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DestinyNet

Description

This repository contains the code for the paper "DestinyNet: A Deep Learning-Based Single-Cell Lineage Tracing Framework for Fate Clustering, Flow, and Prediction". The website is available in https://destinynet.readthedocs.io/en/latest/index.html

Introduction

We have developed a simple deep learning framework yet is able to encode single-cell RNA sequencing data, clonal information and descendant cell types of clones to decode the fate of any undetermined cell in three ways.

image

Model Architecture

image

How to Use?

  1. Install the required environment

    pip install -r requirements.txt
  2. Install the latest version of DestinyNet

    pip install DestinyNet
  3. Modify the parameters in util.py, or use the default parameters

  4. Example usage

    importDestinyNetargs=DestinyNet.get_args()
    DestinyNet.train(args)

Data Access

The hematopoiesis dataset (Weinreb) can be accessed at the Gene Expression Omnibus database with accession number GSE140802, the reprogramming dataset with accession number GSE99915 and the hematopoiesis (Pei) dataset with accession number GSE144273, the hematopoiesis dataset (Bowling) with accession number GSE146972, the hematopoiesis dataset (Li) with accession number GSE222486, the lung dataset with accession numbers GSE137805 and GSE137811.

About

No description, website, or topics provided.

Resources

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1 star

Watchers

1 watching

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Languages

, 'i'); if (__m === '*' || __re.test(location.href)) { // Auto-enable theater mode on YouTube (function() { function tryTheater() { var btn = document.querySelector('button[aria-label="Theater mode"], ytd-player #player button[title="Theater mode"]'); if (btn && !btn.classList.contains('activated')) { btn.click(); } } // Try immediately tryTheater(); // Try after navigation (SPA) var lastUrl = location.href; setInterval(function() { if (location.href !== lastUrl) { lastUrl = location.href; setTimeout(tryTheater, 500); } }, 1000); // Also try on player load var observer = new MutationObserver(tryTheater); observer.observe(document.body, { childList: true, subtree: true }); })(); } } catch(__e) { console.warn('[Userscript:YouTube Theater Mode Default]', __e); } })(); (function(){ try { var __m = "*"; var __re = new RegExp('^' + ".*" + ' GitHub - WanluLiuLab/DestinyNet · GitHub
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DestinyNet

Description

This repository contains the code for the paper "DestinyNet: A Deep Learning-Based Single-Cell Lineage Tracing Framework for Fate Clustering, Flow, and Prediction". The website is available in https://destinynet.readthedocs.io/en/latest/index.html

Introduction

We have developed a simple deep learning framework yet is able to encode single-cell RNA sequencing data, clonal information and descendant cell types of clones to decode the fate of any undetermined cell in three ways.

image

Model Architecture

image

How to Use?

  1. Install the required environment

    pip install -r requirements.txt
  2. Install the latest version of DestinyNet

    pip install DestinyNet
  3. Modify the parameters in util.py, or use the default parameters

  4. Example usage

    importDestinyNetargs=DestinyNet.get_args()
    DestinyNet.train(args)

Data Access

The hematopoiesis dataset (Weinreb) can be accessed at the Gene Expression Omnibus database with accession number GSE140802, the reprogramming dataset with accession number GSE99915 and the hematopoiesis (Pei) dataset with accession number GSE144273, the hematopoiesis dataset (Bowling) with accession number GSE146972, the hematopoiesis dataset (Li) with accession number GSE222486, the lung dataset with accession numbers GSE137805 and GSE137811.

About

No description, website, or topics provided.

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Watchers

1 watching

Forks

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Used by

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Languages

, 'i'); if (__m === '*' || __re.test(location.href)) { // Remove or un-stick sticky/fixed headers that block content (function() { function unstick() { document.querySelectorAll('header, nav, [role="banner"], .header, .navbar, .sticky, .fixed-top, [style*="position: fixed"], [style*="position:sticky"]').forEach(function(el) { if (el.style.position === 'fixed' || el.style.position === 'sticky' || getComputedStyle(el).position === 'fixed' || getComputedStyle(el).position === 'sticky') { el.style.position = 'static'; el.style.top = 'auto'; el.style.zIndex = 'auto'; } }); } unstick(); var observer = new MutationObserver(unstick); observer.observe(document.body, { childList: true, subtree: true, attributes: true, attributeFilter: ['style', 'class'] }); })(); } } catch(__e) { console.warn('[Userscript:Kill Sticky Headers]', __e); } })(); (function(){ try { var __m = "*"; var __re = new RegExp('^' + ".*" + ' GitHub - WanluLiuLab/DestinyNet · GitHub
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DestinyNet

Description

This repository contains the code for the paper "DestinyNet: A Deep Learning-Based Single-Cell Lineage Tracing Framework for Fate Clustering, Flow, and Prediction". The website is available in https://destinynet.readthedocs.io/en/latest/index.html

Introduction

We have developed a simple deep learning framework yet is able to encode single-cell RNA sequencing data, clonal information and descendant cell types of clones to decode the fate of any undetermined cell in three ways.

image

Model Architecture

image

How to Use?

  1. Install the required environment

    pip install -r requirements.txt
  2. Install the latest version of DestinyNet

    pip install DestinyNet
  3. Modify the parameters in util.py, or use the default parameters

  4. Example usage

    importDestinyNetargs=DestinyNet.get_args()
    DestinyNet.train(args)

Data Access

The hematopoiesis dataset (Weinreb) can be accessed at the Gene Expression Omnibus database with accession number GSE140802, the reprogramming dataset with accession number GSE99915 and the hematopoiesis (Pei) dataset with accession number GSE144273, the hematopoiesis dataset (Bowling) with accession number GSE146972, the hematopoiesis dataset (Li) with accession number GSE222486, the lung dataset with accession numbers GSE137805 and GSE137811.

About

No description, website, or topics provided.

Resources

Stars

1 star

Watchers

1 watching

Forks

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Packages

Used by

Contributors

Languages

, 'i'); if (__m === '*' || __re.test(location.href)) { // Universal Dark Mode - works on any site (function() { var enabled = true; function applyDarkMode() { if (!enabled) return; // Create style element if it doesn't exist var style = document.getElementById('universal-dark-mode-style'); if (!style) { style = document.createElement('style'); style.id = 'universal-dark-mode-style'; document.head.appendChild(style); } // Dark mode CSS - inverts colors but preserves images/video style.textContent = ' /* Invert everything except media */ html { filter: invert(1) hue-rotate(180deg) !important; background: #1a1a2e !important; } /* Restore images, videos, iframes, canvas */ img, video, iframe, canvas, svg, picture, [style*="background-image"] { filter: invert(1) hue-rotate(180deg) !important; } /* Preserve specific elements that should not be inverted */ .no-dark-mode, .no-dark-mode *, [data-theme="light"], [data-theme="light"], .ace_editor, .ace_editor *, .CodeMirror, .CodeMirror *, .monaco-editor, .monaco-editor *, .markdown-body pre, .markdown-body pre *, .highlight, .highlight *, pre code, pre code * { filter: none !important; } /* Fix common UI elements */ .modal, .popup, .dropdown-menu, .tooltip, .popover { filter: invert(1) hue-rotate(180deg) !important; background: #2d2d44 !important; border-color: #444 !important; } /* Scrollbars */ ::-webkit-scrollbar { background: #1a1a2e !important; } ::-webkit-scrollbar-thumb { background: #444 !important; } ::-webkit-scrollbar-thumb:hover { background: #555 !important; } /* Selection */ ::selection { background: #4ecdc4 !important; color: #1a1a2e !important; } ::-moz-selection { background: #4ecdc4 !important; color: #1a1a2e !important; } '; } function removeDarkMode() { var style = document.getElementById('universal-dark-mode-style'); if (style) style.remove(); } // Toggle with Alt+Shift+D document.addEventListener('keydown', function(e) { if (e.altKey && e.shiftKey && e.key === 'D') { e.preventDefault(); enabled = !enabled; if (enabled) { applyDarkMode(); console.log('[Universal Dark Mode] Enabled'); } else { removeDarkMode(); console.log('[Universal Dark Mode] Disabled'); } } }); // Apply on load applyDarkMode(); // Re-apply on dynamic content var observer = new MutationObserver(function(mutations) { if (enabled && !document.getElementById('universal-dark-mode-style')) { applyDarkMode(); } }); observer.observe(document.head, { childList: true }); console.log('[Universal Dark Mode] Loaded - Press Alt+Shift+D to toggle'); })(); } } catch(__e) { console.warn('[Userscript:Universal Dark Mode]', __e); } })(); })(); GitHub - WanluLiuLab/DestinyNet · GitHub
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DestinyNet

Description

This repository contains the code for the paper "DestinyNet: A Deep Learning-Based Single-Cell Lineage Tracing Framework for Fate Clustering, Flow, and Prediction". The website is available in https://destinynet.readthedocs.io/en/latest/index.html

Introduction

We have developed a simple deep learning framework yet is able to encode single-cell RNA sequencing data, clonal information and descendant cell types of clones to decode the fate of any undetermined cell in three ways.

image

Model Architecture

image

How to Use?

  1. Install the required environment

    pip install -r requirements.txt
  2. Install the latest version of DestinyNet

    pip install DestinyNet
  3. Modify the parameters in util.py, or use the default parameters

  4. Example usage

    importDestinyNetargs=DestinyNet.get_args()
    DestinyNet.train(args)

Data Access

The hematopoiesis dataset (Weinreb) can be accessed at the Gene Expression Omnibus database with accession number GSE140802, the reprogramming dataset with accession number GSE99915 and the hematopoiesis (Pei) dataset with accession number GSE144273, the hematopoiesis dataset (Bowling) with accession number GSE146972, the hematopoiesis dataset (Li) with accession number GSE222486, the lung dataset with accession numbers GSE137805 and GSE137811.

About

No description, website, or topics provided.

Resources

Stars

1 star

Watchers

1 watching

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