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Mathematical Foundations of Bioinformatics

Overview

  • Instructor: Alireza Fotuhi (ar.fotuhi at gmail.com) & Hesam Montazeri (hesam.montazeri at ut.ac.ir)
  • Teaching Assistants: Marzieh Gholami (at ut.ac.ir)
  • Time & Location: Sundays and Tuesdays 10:00-12:00 at Ghods st. 37, Department of Bioinformatics, IBB, Tehran.

Textbooks

  • [ITP] Blitzstein, Joseph K., and Jessica Hwang. Introduction to probability. Crc Press, 2019 (download)
  • [OpI] Diez, David M., Christopher D. Barr, and Mine Cetinkaya-Rundel. OpenIntro statistics. OpenIntro, Fourth Edition, 2019.
  • [MML] Deisenroth, Marc Peter, A. Aldo Faisal, and Cheng Soon Ong. Mathematics for machine learning. Cambridge University Press, 2020.
  • [DMA] Rosen, Kenneth H., and Kamala Krithivasan. Discrete mathematics and its applications: with combinatorics and graph theory. Tata McGraw-Hill Education, 2012.
  • [MSDA] John A. Rice, Mathematical Statistics And Data Analysis, Third edition, 2007.
  • [PRML] Pattern Recognition and Machine Learning by Christopher Bishop, 2006.

Previous Offerings

Lecture Schedule

Module A: Probability

LectureReading Assignments
Lecture A1- Introduction to probability; counting; Birthday paradox; story proof; probability axioms; inclusion-exclusion principle (slides, video A1)Required: ITP, Ch. 1
Lecture A2- conditional probability (slides)

Conditional probability; Two children problem (video A2-part 1)
Bayes’ rule; the law of total probability; Random coin problem; Testing for a rare disease (video A2-part 2)
Bayes' rule with extra conditioning, independenc; coherency of Bayes' rule (video A2-part 3)
Monty Hall problem, Simpson’s paradox, Gambler’s ruin (video A2-part 4)
Required: ITP, Ch. 2
Lecture A3- random variables and their distributions (slides)

Random variables; PMF (video A3-part 1)
Bernoulli and Binomial distributions (video A3-part 2)
Hypergeometric distribution (video A3-part 3)
Discrete Uniform distribution; Random slips of paper example (video A3-part 4)
Cumulative distribution function; independence of random variables (video A3-part 5)
Conditional independence; Fisher exact test (video A3-part 6)
Required: ITP, Ch. 3
Lecture A4- Expectation (slides)

Expectation; linearity of expectation (video A4-part 1)
Geometric and negative binomial distributions (video A4-part 2)
Indicator Random Variables (video A4-part 3)
LOTUS; Variance (video A4-part 4)
Poisson distribution (video A4-part 5)
Poisson approximation; Poisson & Binomial relationship (video A4-part 6)
Required: ITP, Ch. 4
Lecture A5- Continuous random variable (slides)

Introduction to continuous random variable (video A5-part 1)
Normal distribution (video A5-part 2)
Exponential distribution; Poisson process (Video A5-part 3)
Exponential distribution-continued (video A5-part 4)
Required: ITP, Ch. 5
Lecture A6- Moments (slides)

Summaries of a distribution (video 6-part 1)
Moment generating functions (video A6-part 2)
Required: ITP, Ch. 6



Programming assignments

HomeworksDeadlineTutorial
HW_P1Mehr 6, 1401Introduction to R, RStudio; Basic plotting functions in R By Sajedeh Bahonar (video)
HW_P2Aban 11, 1401Oncoplots



Textbook assignments

TextbookChapterHomeworks
ITPCh. 110, 11, 14, 18, 40, 49, 60
ITPCh. 23, 37, 60, 62, 68, 73
ITPCh. 31, 3, 8, 14, 19, 22, 26, 27, 30, 31, 34, 38
ITPCh. 47, 16a, 26, 31, 33, 39, 49, 53, 54, 69, 71, 89, 91
ITPCh. 51, 5, 8, 14, 22, 28, 40a, 41, 44, 45, 58, 61, 62ab
ITPCh. 61, 15, 17, 22
OpICh. 12, 4, 8, 10, 22, 30, 34, 38, 40, 42
OpICh. 22, 6, 10, 14, 16, 22, 28, 34
OpICh. 54, 6, 8, 10, 12
MSDACh. 767
MSDACh. 87a-c, 45

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