topicsAbsorption modelsSequential Zero-/first-order absorptionParallel zero-/first-order absorptionTime-varying KATransit model with estimated compartment numberInfusionModeling rate and durationPopulation modelingMixture modelssimeta exampleInter-occasion variabilitySimulate from bootstrap parameter estimatesError modelsSigma-Like THETAData setsInput data setsApplicationSimulating large time-to-event trialsSobol sensitivity analysis - with sensobol packageSobol sensitivity analysis - with sensitivity packageLocal sensitivity analysis - with mrgsim.saGraphical sensitivity analysis - with mrgsim.saParallel simulationEstimate parameters for two endpointsAdaptive dosing examplesSimple adaptive dosing