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p-gueguen/README.md

Hi there 👋

I'm a Bioinformatician at FGCZ – ETH Zurich, specializing in single-cell and spatial transcriptomics.

🔬 What I do

I support researchers across Switzerland with cutting-edge genomics technologies, including:

  • Spatial platforms: 10x Xenium, VisiumHD, CosMx
  • Single-cell: 10x Chromium, BD Rhapsody
  • Analysis: Multi-omics integration, immune profiling, custom pipelines

🛠️ Featured projects

🤖 spatial-scribe - Self-serve spatial-transcriptomics analysis, built with Claude: a guided wizard, an interactive spatial canvas, and plain-language questions take you from a raw Xenium/CosMx section to annotated cell types and a shareable report, with honest per-cell confidence.

rctd-py - GPU-accelerated RCTD for spatial transcriptomics.

📍 Spatial_transcriptomics_tools - A curated list of spatial transcriptomics analysis tools organized by category (segmentation, deconvolution, spatial domains, etc.)

📏 spatial-anno-metrics - Quality metrics for spatial cell-type annotation: internal validity, marker-program fidelity, deconvolution, and spatial signal QC.

💬 Let's connect

I'm always happy to discuss single-cell, spatial biology, or AI/ML applications in genomics.


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  1. Spatial_transcriptomics_toolsSpatial_transcriptomics_toolsPublic

    List of Spatial Transcriptomics related Tools organized per category

    Python 200 36

  2. rctd-pyrctd-pyPublic

    GPU-accelerated RCTD for spatial transcriptomics

    Python 50 6

  3. spatial-scribespatial-scribePublic

    A fast, self-serve spatial-transcriptomics analysis copilot for wet-lab scientists (Xenium/CosMx/MERSCOPE). Guided rails + interactive canvas + grounded Claude copilot. Built with Claude.

    Python 5

  4. spatial-anno-metricsspatial-anno-metricsPublic

    Spatial cell-type annotation quality metrics: internal validity (scTypeEval), marker-program fidelity, external harness, deconvolution (OpenProblems), and spatial signal QC (SpatialQM).

    Python 1

  5. carmonalab/CD8_human_TIL_atlas_constructioncarmonalab/CD8_human_TIL_atlas_constructionPublic

    Python 6

  6. single_cell_NSCLCsingle_cell_NSCLCPublic

    Jupyter Notebook 3 3