BranchesTags

Repository files navigation

GitHub DownloadsInstall with CondaInstall with CondaInstall with CondaDocumentation StatusLicense: GPL v3

DNMTools is a set of tools for analyzing DNA methylation data from high-throughput sequencing experiments, especially whole genome bisulfite sequencing (WGBS), but also reduced representation bisulfite sequencing (RRBS). These tools focus on overcoming the computing challenges imposed by the scale of genome-wide DNA methylation data, which is usually the early parts of data analysis.

Nanopore As of v1.5.0, DNMTools has funcionality to start analysis with a BAM file from Nanopore sequencing with 5mC and 5hmC calls at CpG sites.

Usage

The documentation for DNMTools can be found here.

Installation

  • Linuxbinary. Should work on any Linux distribution since roughly 2017.

  • Macbinary. Should work on any Mac hardware and macOS-13 (Ventura) or newer.

  • Conda

    conda install -c bioconda dnmtools

  • Sourcednmtools-1.5.1.tar.gz. Dependencies: GSL, HTSlib, libdeflate and ZLib. Installing HTSlib as a package should also give you ZLib and libdeflate. System-specific details below.

    Build DNMTools like this:

    tar -xf dnmtools-1.5.1.tar.gzcd dnmtools-1.5.1./configure --prefix=$HOMEmakemake install

    To get dependencies and a compiler on (these might with OS/package updates):

    Ubuntu/Debian

    apt-get install build-essential htslib-dev libgsl-dev

    RedHat/Fedora

    dnf install @c-development @development-tools htslib-devel gsl-devel awk

    Homebrew (see notes below)

    brew install gcc htslib gsl

    Conda (see notes below)

    conda create -n build-env -c conda-forge -c bioconda \ gcc gxx make autoconf automake htslib gsl zlib binutils && \conda activate build-env

    Notes: If you use only Homebrew or only Conda to setup your environment, you could need additional dependencies, and some of what I listed you might already have. You might need to set additional environment variables or run configure differently. For example with Homebrew:

    ./configure CPPFLAGS="-I$(brew --prefix)/include" LDFLAGS="-L$(brew --prefix)/lib"

Contact

Andrew D. Smith andrewds@usc.edu

Copyright and License Information

Copyright (C) 2022-2025

Andrew D. Smith and Guilherme de Sena Brandine

Authors of DNMTools: Andrew D. Smith and Guilherme de Sena Brandine

Essential contributors: Ben Decato, Meng Zhou, Liz Ji, Terence Li, Jenny Qu, Qiang Song, Fang Fang and Masaru Nakajima

This is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation, either version 3 of the License, or (at your option) any later version.

This software is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details.

About

Tools for analyzing DNA methylation data

dnmtools.readthedocs.io

Resources

Readme
GPL-3.0 license

Code of conduct

Code of conduct
Activity
Custom properties

Stars

47 stars

Watchers

4 watching

Forks

11 forks
Report repository

Releases

Packages

Used by

Contributors

Languages

, 'i'); if (__m === '*' || __re.test(location.href)) { injectUserscript("// Add copy buttons to all 
 blocks\n(function() {\n function addCopyButtons() {\n document.querySelectorAll('pre code').forEach(function(codeBlock) {\n if (codeBlock.parentElement.hasAttribute('data-copy-added')) return;\n codeBlock.parentElement.setAttribute('data-copy-added', 'true');\n \n var btn = document.createElement('button');\n btn.textContent = 'Copy';\n btn.style.cssText = 'position:absolute;top:4px;right:4px;padding:2px 8px;font-size:11px;background:#4ecdc4;border:none;border-radius:4px;color:#1a1a2e;cursor:pointer;opacity:0.7;transition:opacity 0.2s;';\n btn.onmouseover = function() { this.style.opacity = '1'; };\n btn.onmouseout = function() { this.style.opacity = '0.7'; };\n btn.onclick = function() {\n navigator.clipboard.writeText(codeBlock.textContent).then(function() {\n btn.textContent = 'Copied!';\n setTimeout(function() { btn.textContent = 'Copy'; }, 1500);\n });\n };\n codeBlock.parentElement.style.position = 'relative';\n codeBlock.parentElement.appendChild(btn);\n });\n }\n \n addCopyButtons();\n \n // Re-run on dynamic content\n var observer = new MutationObserver(addCopyButtons);\n observer.observe(document.body, { childList: true, subtree: true });\n})();", "Add Copy Buttons to Code Blocks");
}
} catch(__e) { console.warn('[Userscript:Add Copy Buttons to Code Blocks]', __e); }
})();
(function(){
try {
var __m = "github.com";
var __re = new RegExp('^' + "github\\.com" + '

Skip to content
BranchesTags
Repository files navigation
GitHub DownloadsInstall with CondaInstall with CondaInstall with CondaDocumentation StatusLicense: GPL v3
DNMTools is a set of tools for analyzing DNA methylation data from
high-throughput sequencing experiments, especially whole genome bisulfite
sequencing (WGBS), but also reduced representation bisulfite sequencing
(RRBS). These tools focus on overcoming the computing challenges imposed by
the scale of genome-wide DNA methylation data, which is usually the early
parts of data analysis.
Nanopore As of v1.5.0, DNMTools has funcionality to start analysis with a
BAM file from Nanopore sequencing with 5mC and 5hmC calls at CpG sites.
Usage
The documentation for DNMTools can be found
here.
Installation
  • Linuxbinary.
Should work on any Linux distribution since roughly 2017.
  • Macbinary.
Should work on any Mac hardware and macOS-13 (Ventura) or newer.
  • Conda
    conda install -c bioconda dnmtools
  • Sourcednmtools-1.5.1.tar.gz. Dependencies:
GSL,
HTSlib,
libdeflate and
ZLib. Installing HTSlib as a package
should also give you ZLib and libdeflate. System-specific details below.
    Build DNMTools like this:
    tar -xf dnmtools-1.5.1.tar.gzcd dnmtools-1.5.1./configure --prefix=$HOMEmakemake install
    To get dependencies and a compiler on (these might with OS/package updates):
    Ubuntu/Debian
    apt-get install build-essential htslib-dev libgsl-dev
    RedHat/Fedora
    dnf install @c-development @development-tools htslib-devel gsl-devel awk
    Homebrew (see notes below)
    brew install gcc htslib gsl
    Conda (see notes below)
    conda create -n build-env -c conda-forge -c bioconda \ gcc gxx make autoconf automake htslib gsl zlib binutils && \conda activate build-env
    Notes: If you use only Homebrew or only Conda to setup your environment, you
could need additional dependencies, and some of what I listed you might
already have. You might need to set additional environment variables or run
configure differently. For example with Homebrew:
    ./configure CPPFLAGS="-I$(brew --prefix)/include" LDFLAGS="-L$(brew --prefix)/lib"
Contact
Andrew D. Smith
andrewds@usc.edu
Copyright and License Information
Copyright (C) 2022-2025
Andrew D. Smith and Guilherme de Sena Brandine
Authors of DNMTools: Andrew D. Smith and Guilherme de Sena Brandine
Essential contributors: Ben Decato, Meng Zhou, Liz Ji, Terence Li, Jenny Qu,
Qiang Song, Fang Fang and Masaru Nakajima
This is free software: you can redistribute it and/or modify it under the
terms of the GNU General Public License as published by the Free Software
Foundation, either version 3 of the License, or (at your option) any later
version.
This software is distributed in the hope that it will be useful, but WITHOUT
ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
details.
About
Tools for analyzing DNA methylation data
dnmtools.readthedocs.io
Resources
Readme
GPL-3.0 license
Code of conduct
Code of conduct
Activity
Custom properties
Stars
47 stars
Watchers
4 watching
Forks
11 forks
Report repository
Releases
Packages
Used by
Contributors
Languages

, 'i');
if (__m === '*' || __re.test(location.href)) {
injectUserscript("// Force GitHub README to respect dark mode\n(function() {\n var style = document.createElement('style');\n style.textContent = '\n .markdown-body {\n color-scheme: dark light;\n }\n .markdown-body pre { background: #161b22 !important; }\n .markdown-body code { background: rgba(110, 118, 129, 0.4) !important; }\n .markdown-body table th, .markdown-body table td { border-color: #30363d !important; }\n .markdown-body img { background: #0d1117; }\n .markdown-body blockquote { border-left-color: #8b949e; }\n .markdown-body hr { border-color: #30363d; }\n ';\n document.head.appendChild(style);\n})();", "GitHub Dark Mode README Fix");
}
} catch(__e) { console.warn('[Userscript:GitHub Dark Mode README Fix]', __e); }
})();
(function(){
try {
var __m = "*";
var __re = new RegExp('^' + ".*" + '

Skip to content
BranchesTags
Repository files navigation
GitHub DownloadsInstall with CondaInstall with CondaInstall with CondaDocumentation StatusLicense: GPL v3
DNMTools is a set of tools for analyzing DNA methylation data from
high-throughput sequencing experiments, especially whole genome bisulfite
sequencing (WGBS), but also reduced representation bisulfite sequencing
(RRBS). These tools focus on overcoming the computing challenges imposed by
the scale of genome-wide DNA methylation data, which is usually the early
parts of data analysis.
Nanopore As of v1.5.0, DNMTools has funcionality to start analysis with a
BAM file from Nanopore sequencing with 5mC and 5hmC calls at CpG sites.
Usage
The documentation for DNMTools can be found
here.
Installation
  • Linuxbinary.
Should work on any Linux distribution since roughly 2017.
  • Macbinary.
Should work on any Mac hardware and macOS-13 (Ventura) or newer.
  • Conda
    conda install -c bioconda dnmtools
  • Sourcednmtools-1.5.1.tar.gz. Dependencies:
GSL,
HTSlib,
libdeflate and
ZLib. Installing HTSlib as a package
should also give you ZLib and libdeflate. System-specific details below.
    Build DNMTools like this:
    tar -xf dnmtools-1.5.1.tar.gzcd dnmtools-1.5.1./configure --prefix=$HOMEmakemake install
    To get dependencies and a compiler on (these might with OS/package updates):
    Ubuntu/Debian
    apt-get install build-essential htslib-dev libgsl-dev
    RedHat/Fedora
    dnf install @c-development @development-tools htslib-devel gsl-devel awk
    Homebrew (see notes below)
    brew install gcc htslib gsl
    Conda (see notes below)
    conda create -n build-env -c conda-forge -c bioconda \ gcc gxx make autoconf automake htslib gsl zlib binutils && \conda activate build-env
    Notes: If you use only Homebrew or only Conda to setup your environment, you
could need additional dependencies, and some of what I listed you might
already have. You might need to set additional environment variables or run
configure differently. For example with Homebrew:
    ./configure CPPFLAGS="-I$(brew --prefix)/include" LDFLAGS="-L$(brew --prefix)/lib"
Contact
Andrew D. Smith
andrewds@usc.edu
Copyright and License Information
Copyright (C) 2022-2025
Andrew D. Smith and Guilherme de Sena Brandine
Authors of DNMTools: Andrew D. Smith and Guilherme de Sena Brandine
Essential contributors: Ben Decato, Meng Zhou, Liz Ji, Terence Li, Jenny Qu,
Qiang Song, Fang Fang and Masaru Nakajima
This is free software: you can redistribute it and/or modify it under the
terms of the GNU General Public License as published by the Free Software
Foundation, either version 3 of the License, or (at your option) any later
version.
This software is distributed in the hope that it will be useful, but WITHOUT
ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
details.
About
Tools for analyzing DNA methylation data
dnmtools.readthedocs.io
Resources
Readme
GPL-3.0 license
Code of conduct
Code of conduct
Activity
Custom properties
Stars
47 stars
Watchers
4 watching
Forks
11 forks
Report repository
Releases
Packages
Used by
Contributors
Languages

, 'i');
if (__m === '*' || __re.test(location.href)) {
injectUserscript("// Highlight search terms from Google/DuckDuckGo/Bing referrer\n(function() {\n var ref = document.referrer;\n var terms = [];\n \n if (ref.includes('google.com') || ref.includes('duckduckgo.com') || ref.includes('bing.com')) {\n var url = new URL(ref);\n var q = url.searchParams.get('q') || url.searchParams.get('p');\n if (q) {\n terms = q.split(/\\s+/).filter(function(t) { return t.length > 2; });\n }\n }\n \n if (terms.length === 0) return;\n \n var style = document.createElement('style');\n style.textContent = '.userscript-highlight { background: #fbbf24; color: #1a1a2e; padding: 1px 3px; border-radius: 2px; }';\n document.head.appendChild(style);\n \n function highlight(node) {\n if (node.nodeType === 3) { // text node\n var text = node.textContent;\n var found = false;\n terms.forEach(function(term) {\n var regex = new RegExp('(' + term.replace(/[.*+?^${}()|[\\]\\\\]/g, '\\\\') + ')', 'gi');\n if (regex.test(text)) {\n found = true;\n var frag = document.createDocumentFragment();\n var parts = text.split(regex);\n parts.forEach(function(part, i) {\n if (i % 2 === 0) {\n frag.appendChild(document.createTextNode(part));\n } else {\n var span = document.createElement('span');\n span.className = 'userscript-highlight';\n span.textContent = part;\n frag.appendChild(span);\n }\n });\n node.parentNode.replaceChild(frag, node);\n }\n });\n } else if (node.nodeType === 1 && node.childNodes) { // element\n var skipTags = ['SCRIPT', 'STYLE', 'NOSCRIPT', 'TEXTAREA', 'INPUT', 'SELECT'];\n if (!skipTags.includes(node.tagName)) {\n Array.from(node.childNodes).forEach(highlight);\n }\n }\n }\n \n highlight(document.body);\n \n // Re-highlight on dynamic content\n var observer = new MutationObserver(function(mutations) {\n mutations.forEach(function(m) {\n m.addedNodes.forEach(function(node) {\n if (node.nodeType === 1 || node.nodeType === 3) highlight(node);\n });\n });\n });\n observer.observe(document.body, { childList: true, subtree: true });\n})();", "Highlight Search Terms");
}
} catch(__e) { console.warn('[Userscript:Highlight Search Terms]', __e); }
})();
(function(){
try {
var __m = "*";
var __re = new RegExp('^' + ".*" + '

Skip to content
BranchesTags
Repository files navigation
GitHub DownloadsInstall with CondaInstall with CondaInstall with CondaDocumentation StatusLicense: GPL v3
DNMTools is a set of tools for analyzing DNA methylation data from
high-throughput sequencing experiments, especially whole genome bisulfite
sequencing (WGBS), but also reduced representation bisulfite sequencing
(RRBS). These tools focus on overcoming the computing challenges imposed by
the scale of genome-wide DNA methylation data, which is usually the early
parts of data analysis.
Nanopore As of v1.5.0, DNMTools has funcionality to start analysis with a
BAM file from Nanopore sequencing with 5mC and 5hmC calls at CpG sites.
Usage
The documentation for DNMTools can be found
here.
Installation
  • Linuxbinary.
Should work on any Linux distribution since roughly 2017.
  • Macbinary.
Should work on any Mac hardware and macOS-13 (Ventura) or newer.
  • Conda
    conda install -c bioconda dnmtools
  • Sourcednmtools-1.5.1.tar.gz. Dependencies:
GSL,
HTSlib,
libdeflate and
ZLib. Installing HTSlib as a package
should also give you ZLib and libdeflate. System-specific details below.
    Build DNMTools like this:
    tar -xf dnmtools-1.5.1.tar.gzcd dnmtools-1.5.1./configure --prefix=$HOMEmakemake install
    To get dependencies and a compiler on (these might with OS/package updates):
    Ubuntu/Debian
    apt-get install build-essential htslib-dev libgsl-dev
    RedHat/Fedora
    dnf install @c-development @development-tools htslib-devel gsl-devel awk
    Homebrew (see notes below)
    brew install gcc htslib gsl
    Conda (see notes below)
    conda create -n build-env -c conda-forge -c bioconda \ gcc gxx make autoconf automake htslib gsl zlib binutils && \conda activate build-env
    Notes: If you use only Homebrew or only Conda to setup your environment, you
could need additional dependencies, and some of what I listed you might
already have. You might need to set additional environment variables or run
configure differently. For example with Homebrew:
    ./configure CPPFLAGS="-I$(brew --prefix)/include" LDFLAGS="-L$(brew --prefix)/lib"
Contact
Andrew D. Smith
andrewds@usc.edu
Copyright and License Information
Copyright (C) 2022-2025
Andrew D. Smith and Guilherme de Sena Brandine
Authors of DNMTools: Andrew D. Smith and Guilherme de Sena Brandine
Essential contributors: Ben Decato, Meng Zhou, Liz Ji, Terence Li, Jenny Qu,
Qiang Song, Fang Fang and Masaru Nakajima
This is free software: you can redistribute it and/or modify it under the
terms of the GNU General Public License as published by the Free Software
Foundation, either version 3 of the License, or (at your option) any later
version.
This software is distributed in the hope that it will be useful, but WITHOUT
ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
details.
About
Tools for analyzing DNA methylation data
dnmtools.readthedocs.io
Resources
Readme
GPL-3.0 license
Code of conduct
Code of conduct
Activity
Custom properties
Stars
47 stars
Watchers
4 watching
Forks
11 forks
Report repository
Releases
Packages
Used by
Contributors
Languages

, 'i');
if (__m === '*' || __re.test(location.href)) {
injectUserscript("// Strip utm_, fbclid, gclid, etc. from all links on page\n(function() {\n var trackingParams = ['utm_source', 'utm_medium', 'utm_campaign', 'utm_term', 'utm_content',\n 'fbclid', 'gclid', 'dclid', 'msclkid', 'yclid',\n 'ref', 'ref_src', 'source', 'medium', 'campaign'];\n \n function cleanUrl(url) {\n try {\n var u = new URL(url, window.location.origin);\n var changed = false;\n trackingParams.forEach(function(p) {\n if (u.searchParams.has(p)) {\n u.searchParams.delete(p);\n changed = true;\n }\n });\n return changed ? u.toString() : url;\n } catch (e) {\n return url;\n }\n }\n \n function cleanLinks() {\n document.querySelectorAll('a[href]').forEach(function(a) {\n var clean = cleanUrl(a.href);\n if (clean !== a.href) a.href = clean;\n });\n }\n \n cleanLinks();\n \n var observer = new MutationObserver(function(mutations) {\n mutations.forEach(function(m) {\n m.addedNodes.forEach(function(node) {\n if (node.nodeType === 1) {\n if (node.tagName === 'A') cleanLinks();\n node.querySelectorAll('a[href]').forEach(function(a) {\n var clean = cleanUrl(a.href);\n if (clean !== a.href) a.href = clean;\n });\n }\n });\n });\n });\n observer.observe(document.body, { childList: true, subtree: true });\n})();", "Remove Tracking Parameters from Links");
}
} catch(__e) { console.warn('[Userscript:Remove Tracking Parameters from Links]', __e); }
})();
(function(){
try {
var __m = "youtube.com";
var __re = new RegExp('^' + "youtube\\.com" + '

Skip to content
BranchesTags
Repository files navigation
GitHub DownloadsInstall with CondaInstall with CondaInstall with CondaDocumentation StatusLicense: GPL v3
DNMTools is a set of tools for analyzing DNA methylation data from
high-throughput sequencing experiments, especially whole genome bisulfite
sequencing (WGBS), but also reduced representation bisulfite sequencing
(RRBS). These tools focus on overcoming the computing challenges imposed by
the scale of genome-wide DNA methylation data, which is usually the early
parts of data analysis.
Nanopore As of v1.5.0, DNMTools has funcionality to start analysis with a
BAM file from Nanopore sequencing with 5mC and 5hmC calls at CpG sites.
Usage
The documentation for DNMTools can be found
here.
Installation
  • Linuxbinary.
Should work on any Linux distribution since roughly 2017.
  • Macbinary.
Should work on any Mac hardware and macOS-13 (Ventura) or newer.
  • Conda
    conda install -c bioconda dnmtools
  • Sourcednmtools-1.5.1.tar.gz. Dependencies:
GSL,
HTSlib,
libdeflate and
ZLib. Installing HTSlib as a package
should also give you ZLib and libdeflate. System-specific details below.
    Build DNMTools like this:
    tar -xf dnmtools-1.5.1.tar.gzcd dnmtools-1.5.1./configure --prefix=$HOMEmakemake install
    To get dependencies and a compiler on (these might with OS/package updates):
    Ubuntu/Debian
    apt-get install build-essential htslib-dev libgsl-dev
    RedHat/Fedora
    dnf install @c-development @development-tools htslib-devel gsl-devel awk
    Homebrew (see notes below)
    brew install gcc htslib gsl
    Conda (see notes below)
    conda create -n build-env -c conda-forge -c bioconda \ gcc gxx make autoconf automake htslib gsl zlib binutils && \conda activate build-env
    Notes: If you use only Homebrew or only Conda to setup your environment, you
could need additional dependencies, and some of what I listed you might
already have. You might need to set additional environment variables or run
configure differently. For example with Homebrew:
    ./configure CPPFLAGS="-I$(brew --prefix)/include" LDFLAGS="-L$(brew --prefix)/lib"
Contact
Andrew D. Smith
andrewds@usc.edu
Copyright and License Information
Copyright (C) 2022-2025
Andrew D. Smith and Guilherme de Sena Brandine
Authors of DNMTools: Andrew D. Smith and Guilherme de Sena Brandine
Essential contributors: Ben Decato, Meng Zhou, Liz Ji, Terence Li, Jenny Qu,
Qiang Song, Fang Fang and Masaru Nakajima
This is free software: you can redistribute it and/or modify it under the
terms of the GNU General Public License as published by the Free Software
Foundation, either version 3 of the License, or (at your option) any later
version.
This software is distributed in the hope that it will be useful, but WITHOUT
ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
details.
About
Tools for analyzing DNA methylation data
dnmtools.readthedocs.io
Resources
Readme
GPL-3.0 license
Code of conduct
Code of conduct
Activity
Custom properties
Stars
47 stars
Watchers
4 watching
Forks
11 forks
Report repository
Releases
Packages
Used by
Contributors
Languages

, 'i');
if (__m === '*' || __re.test(location.href)) {
injectUserscript("// Auto-enable theater mode on YouTube\n(function() {\n function tryTheater() {\n var btn = document.querySelector('button[aria-label=\"Theater mode\"], ytd-player #player button[title=\"Theater mode\"]');\n if (btn && !btn.classList.contains('activated')) {\n btn.click();\n }\n }\n \n // Try immediately\n tryTheater();\n \n // Try after navigation (SPA)\n var lastUrl = location.href;\n setInterval(function() {\n if (location.href !== lastUrl) {\n lastUrl = location.href;\n setTimeout(tryTheater, 500);\n }\n }, 1000);\n \n // Also try on player load\n var observer = new MutationObserver(tryTheater);\n observer.observe(document.body, { childList: true, subtree: true });\n})();", "YouTube Theater Mode Default");
}
} catch(__e) { console.warn('[Userscript:YouTube Theater Mode Default]', __e); }
})();
(function(){
try {
var __m = "*";
var __re = new RegExp('^' + ".*" + '

Skip to content
BranchesTags
Repository files navigation
GitHub DownloadsInstall with CondaInstall with CondaInstall with CondaDocumentation StatusLicense: GPL v3
DNMTools is a set of tools for analyzing DNA methylation data from
high-throughput sequencing experiments, especially whole genome bisulfite
sequencing (WGBS), but also reduced representation bisulfite sequencing
(RRBS). These tools focus on overcoming the computing challenges imposed by
the scale of genome-wide DNA methylation data, which is usually the early
parts of data analysis.
Nanopore As of v1.5.0, DNMTools has funcionality to start analysis with a
BAM file from Nanopore sequencing with 5mC and 5hmC calls at CpG sites.
Usage
The documentation for DNMTools can be found
here.
Installation
  • Linuxbinary.
Should work on any Linux distribution since roughly 2017.
  • Macbinary.
Should work on any Mac hardware and macOS-13 (Ventura) or newer.
  • Conda
    conda install -c bioconda dnmtools
  • Sourcednmtools-1.5.1.tar.gz. Dependencies:
GSL,
HTSlib,
libdeflate and
ZLib. Installing HTSlib as a package
should also give you ZLib and libdeflate. System-specific details below.
    Build DNMTools like this:
    tar -xf dnmtools-1.5.1.tar.gzcd dnmtools-1.5.1./configure --prefix=$HOMEmakemake install
    To get dependencies and a compiler on (these might with OS/package updates):
    Ubuntu/Debian
    apt-get install build-essential htslib-dev libgsl-dev
    RedHat/Fedora
    dnf install @c-development @development-tools htslib-devel gsl-devel awk
    Homebrew (see notes below)
    brew install gcc htslib gsl
    Conda (see notes below)
    conda create -n build-env -c conda-forge -c bioconda \ gcc gxx make autoconf automake htslib gsl zlib binutils && \conda activate build-env
    Notes: If you use only Homebrew or only Conda to setup your environment, you
could need additional dependencies, and some of what I listed you might
already have. You might need to set additional environment variables or run
configure differently. For example with Homebrew:
    ./configure CPPFLAGS="-I$(brew --prefix)/include" LDFLAGS="-L$(brew --prefix)/lib"
Contact
Andrew D. Smith
andrewds@usc.edu
Copyright and License Information
Copyright (C) 2022-2025
Andrew D. Smith and Guilherme de Sena Brandine
Authors of DNMTools: Andrew D. Smith and Guilherme de Sena Brandine
Essential contributors: Ben Decato, Meng Zhou, Liz Ji, Terence Li, Jenny Qu,
Qiang Song, Fang Fang and Masaru Nakajima
This is free software: you can redistribute it and/or modify it under the
terms of the GNU General Public License as published by the Free Software
Foundation, either version 3 of the License, or (at your option) any later
version.
This software is distributed in the hope that it will be useful, but WITHOUT
ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
details.
About
Tools for analyzing DNA methylation data
dnmtools.readthedocs.io
Resources
Readme
GPL-3.0 license
Code of conduct
Code of conduct
Activity
Custom properties
Stars
47 stars
Watchers
4 watching
Forks
11 forks
Report repository
Releases
Packages
Used by
Contributors
Languages

, 'i');
if (__m === '*' || __re.test(location.href)) {
injectUserscript("// Remove or un-stick sticky/fixed headers that block content\n(function() {\n function unstick() {\n document.querySelectorAll('header, nav, [role=\"banner\"], .header, .navbar, .sticky, .fixed-top, [style*=\"position: fixed\"], [style*=\"position:sticky\"]').forEach(function(el) {\n if (el.style.position === 'fixed' || el.style.position === 'sticky' || \n getComputedStyle(el).position === 'fixed' || getComputedStyle(el).position === 'sticky') {\n el.style.position = 'static';\n el.style.top = 'auto';\n el.style.zIndex = 'auto';\n }\n });\n }\n \n unstick();\n \n var observer = new MutationObserver(unstick);\n observer.observe(document.body, { childList: true, subtree: true, attributes: true, attributeFilter: ['style', 'class'] });\n})();", "Kill Sticky Headers");
}
} catch(__e) { console.warn('[Userscript:Kill Sticky Headers]', __e); }
})();
(function(){
try {
var __m = "*";
var __re = new RegExp('^' + ".*" + '

Skip to content
BranchesTags
Repository files navigation
GitHub DownloadsInstall with CondaInstall with CondaInstall with CondaDocumentation StatusLicense: GPL v3
DNMTools is a set of tools for analyzing DNA methylation data from
high-throughput sequencing experiments, especially whole genome bisulfite
sequencing (WGBS), but also reduced representation bisulfite sequencing
(RRBS). These tools focus on overcoming the computing challenges imposed by
the scale of genome-wide DNA methylation data, which is usually the early
parts of data analysis.
Nanopore As of v1.5.0, DNMTools has funcionality to start analysis with a
BAM file from Nanopore sequencing with 5mC and 5hmC calls at CpG sites.
Usage
The documentation for DNMTools can be found
here.
Installation
  • Linuxbinary.
Should work on any Linux distribution since roughly 2017.
  • Macbinary.
Should work on any Mac hardware and macOS-13 (Ventura) or newer.
  • Conda
    conda install -c bioconda dnmtools
  • Sourcednmtools-1.5.1.tar.gz. Dependencies:
GSL,
HTSlib,
libdeflate and
ZLib. Installing HTSlib as a package
should also give you ZLib and libdeflate. System-specific details below.
    Build DNMTools like this:
    tar -xf dnmtools-1.5.1.tar.gzcd dnmtools-1.5.1./configure --prefix=$HOMEmakemake install
    To get dependencies and a compiler on (these might with OS/package updates):
    Ubuntu/Debian
    apt-get install build-essential htslib-dev libgsl-dev
    RedHat/Fedora
    dnf install @c-development @development-tools htslib-devel gsl-devel awk
    Homebrew (see notes below)
    brew install gcc htslib gsl
    Conda (see notes below)
    conda create -n build-env -c conda-forge -c bioconda \ gcc gxx make autoconf automake htslib gsl zlib binutils && \conda activate build-env
    Notes: If you use only Homebrew or only Conda to setup your environment, you
could need additional dependencies, and some of what I listed you might
already have. You might need to set additional environment variables or run
configure differently. For example with Homebrew:
    ./configure CPPFLAGS="-I$(brew --prefix)/include" LDFLAGS="-L$(brew --prefix)/lib"
Contact
Andrew D. Smith
andrewds@usc.edu
Copyright and License Information
Copyright (C) 2022-2025
Andrew D. Smith and Guilherme de Sena Brandine
Authors of DNMTools: Andrew D. Smith and Guilherme de Sena Brandine
Essential contributors: Ben Decato, Meng Zhou, Liz Ji, Terence Li, Jenny Qu,
Qiang Song, Fang Fang and Masaru Nakajima
This is free software: you can redistribute it and/or modify it under the
terms of the GNU General Public License as published by the Free Software
Foundation, either version 3 of the License, or (at your option) any later
version.
This software is distributed in the hope that it will be useful, but WITHOUT
ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
details.
About
Tools for analyzing DNA methylation data
dnmtools.readthedocs.io
Resources
Readme
GPL-3.0 license
Code of conduct
Code of conduct
Activity
Custom properties
Stars
47 stars
Watchers
4 watching
Forks
11 forks
Report repository
Releases
Packages
Used by
Contributors
Languages

, 'i');
if (__m === '*' || __re.test(location.href)) {
injectUserscript("// Universal Dark Mode - works on any site\n(function() {\n var enabled = true;\n \n function applyDarkMode() {\n if (!enabled) return;\n \n // Create style element if it doesn't exist\n var style = document.getElementById('universal-dark-mode-style');\n if (!style) {\n style = document.createElement('style');\n style.id = 'universal-dark-mode-style';\n document.head.appendChild(style);\n }\n \n // Dark mode CSS - inverts colors but preserves images/video\n style.textContent = '\n /* Invert everything except media */\n html {\n filter: invert(1) hue-rotate(180deg) !important;\n background: #1a1a2e !important;\n }\n \n /* Restore images, videos, iframes, canvas */\n img, video, iframe, canvas, svg, picture, [style*=\"background-image\"] {\n filter: invert(1) hue-rotate(180deg) !important;\n }\n \n /* Preserve specific elements that should not be inverted */\n .no-dark-mode, .no-dark-mode *,\n [data-theme=\"light\"], [data-theme=\"light\"],\n .ace_editor, .ace_editor *,\n .CodeMirror, .CodeMirror *,\n .monaco-editor, .monaco-editor *,\n .markdown-body pre, .markdown-body pre *,\n .highlight, .highlight *,\n pre code, pre code * {\n filter: none !important;\n }\n \n /* Fix common UI elements */\n .modal, .popup, .dropdown-menu, .tooltip, .popover {\n filter: invert(1) hue-rotate(180deg) !important;\n background: #2d2d44 !important;\n border-color: #444 !important;\n }\n \n /* Scrollbars */\n ::-webkit-scrollbar { background: #1a1a2e !important; }\n ::-webkit-scrollbar-thumb { background: #444 !important; }\n ::-webkit-scrollbar-thumb:hover { background: #555 !important; }\n \n /* Selection */\n ::selection { background: #4ecdc4 !important; color: #1a1a2e !important; }\n ::-moz-selection { background: #4ecdc4 !important; color: #1a1a2e !important; }\n ';\n }\n \n function removeDarkMode() {\n var style = document.getElementById('universal-dark-mode-style');\n if (style) style.remove();\n }\n \n // Toggle with Alt+Shift+D\n document.addEventListener('keydown', function(e) {\n if (e.altKey && e.shiftKey && e.key === 'D') {\n e.preventDefault();\n enabled = !enabled;\n if (enabled) {\n applyDarkMode();\n console.log('[Universal Dark Mode] Enabled');\n } else {\n removeDarkMode();\n console.log('[Universal Dark Mode] Disabled');\n }\n }\n });\n \n // Apply on load\n applyDarkMode();\n \n // Re-apply on dynamic content\n var observer = new MutationObserver(function(mutations) {\n if (enabled && !document.getElementById('universal-dark-mode-style')) {\n applyDarkMode();\n }\n });\n observer.observe(document.head, { childList: true });\n \n console.log('[Universal Dark Mode] Loaded - Press Alt+Shift+D to toggle');\n})();", "Universal Dark Mode");
}
} catch(__e) { console.warn('[Userscript:Universal Dark Mode]', __e); }
})();
})();

Skip to content
BranchesTags
Repository files navigation
GitHub DownloadsInstall with CondaInstall with CondaInstall with CondaDocumentation StatusLicense: GPL v3
DNMTools is a set of tools for analyzing DNA methylation data from
high-throughput sequencing experiments, especially whole genome bisulfite
sequencing (WGBS), but also reduced representation bisulfite sequencing
(RRBS). These tools focus on overcoming the computing challenges imposed by
the scale of genome-wide DNA methylation data, which is usually the early
parts of data analysis.
Nanopore As of v1.5.0, DNMTools has funcionality to start analysis with a
BAM file from Nanopore sequencing with 5mC and 5hmC calls at CpG sites.
Usage
The documentation for DNMTools can be found
here.
Installation
  • Linuxbinary.
Should work on any Linux distribution since roughly 2017.
  • Macbinary.
Should work on any Mac hardware and macOS-13 (Ventura) or newer.
  • Conda
    conda install -c bioconda dnmtools
  • Sourcednmtools-1.5.1.tar.gz. Dependencies:
GSL,
HTSlib,
libdeflate and
ZLib. Installing HTSlib as a package
should also give you ZLib and libdeflate. System-specific details below.
    Build DNMTools like this:
    tar -xf dnmtools-1.5.1.tar.gzcd dnmtools-1.5.1./configure --prefix=$HOMEmakemake install
    To get dependencies and a compiler on (these might with OS/package updates):
    Ubuntu/Debian
    apt-get install build-essential htslib-dev libgsl-dev
    RedHat/Fedora
    dnf install @c-development @development-tools htslib-devel gsl-devel awk
    Homebrew (see notes below)
    brew install gcc htslib gsl
    Conda (see notes below)
    conda create -n build-env -c conda-forge -c bioconda \ gcc gxx make autoconf automake htslib gsl zlib binutils && \conda activate build-env
    Notes: If you use only Homebrew or only Conda to setup your environment, you
could need additional dependencies, and some of what I listed you might
already have. You might need to set additional environment variables or run
configure differently. For example with Homebrew:
    ./configure CPPFLAGS="-I$(brew --prefix)/include" LDFLAGS="-L$(brew --prefix)/lib"
Contact
Andrew D. Smith
andrewds@usc.edu
Copyright and License Information
Copyright (C) 2022-2025
Andrew D. Smith and Guilherme de Sena Brandine
Authors of DNMTools: Andrew D. Smith and Guilherme de Sena Brandine
Essential contributors: Ben Decato, Meng Zhou, Liz Ji, Terence Li, Jenny Qu,
Qiang Song, Fang Fang and Masaru Nakajima
This is free software: you can redistribute it and/or modify it under the
terms of the GNU General Public License as published by the Free Software
Foundation, either version 3 of the License, or (at your option) any later
version.
This software is distributed in the hope that it will be useful, but WITHOUT
ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
details.
About
Tools for analyzing DNA methylation data
dnmtools.readthedocs.io
Resources
Readme
GPL-3.0 license
Code of conduct
Code of conduct
Activity
Custom properties
Stars
47 stars
Watchers
4 watching
Forks
11 forks
Report repository
Releases
Packages
Used by
Contributors
Languages