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A variant-first, multi-modality CRISPR design framework that unifies SpCas9 nuclease, base-editor, and prime-editor chemistries under a single typed interface to deliver ranked candidate edits complete with calibrated uncertainty intervals, predicted outcome distributions, and ancestry-stratified, population-aware off-target safety reporting.
Repository of R functions and files to derive estimates and generate simulated data according to the methods and models described in "Bias-corrected maximum-likelihood estimation of multiplicity of infection and lineage frequencies". To import/merge molecular data of any type (STR, SNPs, amino acids) and format and apply further analysis use R/MLMO