dose-selection

Here are 2 public repositories matching this topic...

tjmb03 / bispecific-fih-dosability

Mechanistic first-in-human dosability screen for tumor-targeted bispecific antibodies — go/no-go and dosability-margin ranking computed from binding parameters, before any dose exists.

pharmacometrics drug-development immuno-oncology first-in-human-clinical-trial mabel quantitative-pharmacology pkpd-modelling ternary-complex bispecific-antibody dose-selection

Updated Jul 2, 2026
Python

tjmb03 / adc-therapeutic-index

Star

Multi-analyte ADC PK/PD and exposure-driven dose selection — therapeutic window and OBD from conjugate efficacy vs. free-payload toxicity, the toxicology paradigm (not MABEL).

adc dar pkpd immuno-oncology pkpd-modelling antibody-drug-conjugates dose-selection multi-analyte therapeutic-index

Updated Jul 2, 2026
Python

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